Novel article on tight relationships between Pma1 H+-ATPase and TORC1 published in PLoS Genetics

The yeast Pma1 H+-ATPase energizes the plasma membrane and is crucial for cell viability. This H+ pump is also involved in initial TORC1 activation upon H+-coupled active uptake of nutrients into starved cells. In this article entitled “Phosphoregulation of the yeast Pma1 H+-ATPase autoinhibitory domain involves the Ptk1/2 kinases and the Glc7 PP1 phosphatase and is under TORC1 control“, we identify the largely redundant Ptk1 and Ptk2 kinases and the Glc7 PP1 phosphatase as the key actors of the phosphoregulation of Pma1. We also unravel that this phosphocontrol, when defective, negatively impacts Pma1-mediated TORC1 regulation, and that TORC1 feedback inhibits Pma1 phosphorylation. This work has been largely carried out by Nadia Guarini thanks to initial observations by Elie Saliba.