B André was invited to give a conference entitled “Diversity and regulation of amino acid transporters in Saccharomyces cerevisiae “at the first plenary sessions of the “Microbiology and Hygiene meeting” organized in Dresden (Germany) (Oct 5-8).
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Our last paper entitled “Substrate-induced ubiquitylation and endocytosis of yeast amino acid permeases” has been accepted for publication in the journal Molecular and Cellular Biology. This work, carried out in collaboration with Martine Prévost and Eva Krammer (ULB), reports that substrate binding to the yeast amino acid transporters Gap1 and Can1 triggers a conformational change eliciting their recognition by arrestin-like adaptors which in turn provokes their ubiquitylation by the Rsp5 ubiquitin ligase and their endocytosis. Similar mechanisms likely control many other plasma membrane secondary transporters according to the external concentration of their substrates.
We are very glad to welcome Dr Christos Gournas as a new FNRS postdoc in the lab. Christos obtained his PhD in 2012 after a research in the excellent lab of Pr. George Diallinas (University of Athens, Greece). Among other contributions he reported one of the clearest case of substrate-induced endocytosis of a nutrient permease in the model fungus Aspergillus nidulans (Gournas et a. 2010). He then moved to the lab of Vicky Sophianopoulou (NCSR “Demokritos”, Athens, Greece) where he studied relationships between the 3D structure and function of amino acid permeases in A. nidulans. He now started a new postdoctoral research in the lab as “Chargé de Recherche” of the FNRS. A commission of ULB selected the application of Forent Corillon for a one-year PhD “assistant” fellowship. Florent, who previously did his master thesis in the lab on the structure-function relatioships of the Ssy1 sensor, will now investigate the signalling properties of the yeast Gap1 permease. He will also be involved in the supervision of practical works for students. Congratulations to him and good luck with this new project. We are pleased to welcome a new pregraduate student, Nathan Fraikin, in the lab. During his master thesis, Nathan will study the role of phosphorylation in the endocytosis and intracellular traffic of the yeast Gap1 permease. B André attended the last “Yeast Genetics meeting” which took place July 29-August 3 in Seattle (USA) at the Washington University. The very interesting program also included a special lecture by George Church (Harvard univ.) about synthetic biology. Below pictures of the campus and Seattle.
On April 3rd, Kassem Ghaddar publicly presented his PhD work entitled “Structural analysis of yeast amino acid transporters : substrate binding and substrate-induced endocytosis” and received his PhD diploma. A great moment for Kassem, who was surrounded by colleages, friends, and family members. Kassem will soon undertake a postdoc in another lab in Begium. Thanks a lot to him for his key contribution to our study of yeast amino acid transporters, and good luck in everything. |
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